Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study
Identifieur interne : 000103 ( Main/Exploration ); précédent : 000102; suivant : 000104Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study
Auteurs : Irene Pichler [Royaume-Uni] ; Fabiola Del [Royaume-Uni] ; Martin Gögele [Royaume-Uni] ; Christina Lill [Allemagne] ; Lars Bertram [Allemagne] ; Chuong Do [États-Unis] ; Nicholas Eriksson [États-Unis] ; Tatiana Foroud [États-Unis] ; Richard Myers [États-Unis] ; Michael Nalls [États-Unis] ; Margaux Keller [États-Unis] ; Beben Benyamin [Australie] ; John Whitfield [Australie] ; Peter Pramstaller [Royaume-Uni, Italie, Allemagne] ; Andrew Hicks [Royaume-Uni] ; John Thompson [Royaume-Uni] ; Cosetta Minelli [Royaume-Uni]Source :
- PLoS Medicine [ 1549-1277 ] ; 2013.
Abstract
In this study, Mendelian randomization was used to study genes known to modify iron levels, and the effect of iron on Parkinson's disease (PD) risk was estimated. Based on estimates of the genetic effects on both iron and PD obtained from the largest sample meta-analyzed to date, the findings suggest that increased iron levels in the blood are associated with a 3% reduction in the risk of Parkinson's disease for every 10 µg/dL increase in iron. The results of this analysis have potentially important implications for future research into the prevention of Parkinson's disease.
Please see later in the article for the Editors' Summary
Url:
DOI: 10.1371/journal.pmed.1001462
PubMed: 23750121
PubMed Central: 3672214
Affiliations:
- Allemagne, Australie, Italie, Royaume-Uni, États-Unis
- Angleterre, Berlin, Californie, Grand Londres, Indiana, Maryland, Massachusetts, Pennsylvanie
- Berlin, Londres
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London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Del Greco M, Fabiola" sort="Del Greco M, Fabiola" uniqKey="Del Greco M F" first="Fabiola" last="Del">Fabiola Del</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gogele, Martin" sort="Gogele, Martin" uniqKey="Gogele M" first="Martin" last="Gögele">Martin Gögele</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lill, Christina M" sort="Lill, Christina M" uniqKey="Lill C" first="Christina" last="Lill">Christina Lill</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Neurology, Medical Center of the Johannes Gutenberg-University, Mainz, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Medical Center of the Johannes Gutenberg-University, Mainz</wicri:regionArea><wicri:noRegion>Mainz</wicri:noRegion><wicri:noRegion>Mainz</wicri:noRegion><wicri:noRegion>Mainz</wicri:noRegion></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Do, Chuong B" sort="Do, Chuong B" uniqKey="Do C" first="Chuong" last="Do">Chuong Do</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>23andMe, Inc., Mountain View, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>23andMe, Inc., Mountain View, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Eriksson, Nicholas" sort="Eriksson, Nicholas" uniqKey="Eriksson N" first="Nicholas" last="Eriksson">Nicholas Eriksson</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>23andMe, Inc., Mountain View, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>23andMe, Inc., Mountain View, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Indiana University School of Medicine, Indianapolis, Indiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard" last="Myers">Richard Myers</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Nalls, Michael" sort="Nalls, Michael" uniqKey="Nalls M" first="Michael" last="Nalls">Michael Nalls</name><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Keller, Margaux F" sort="Keller, Margaux F" uniqKey="Keller M" first="Margaux" last="Keller">Margaux Keller</name><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Department of Biological Anthropology, Temple University, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Anthropology, Temple University, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name><affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Queensland Institute of Medical Research, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10"><addr-line>Queensland Brain Institute, The University of Queensland, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Brain Institute, The University of Queensland, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John" last="Whitfield">John Whitfield</name><affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Queensland Institute of Medical Research, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter" last="Pramstaller">Peter Pramstaller</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>Department of Neurology, General Central Hospital, Bolzano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, General Central Hospital, Bolzano</wicri:regionArea><wicri:noRegion>Bolzano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Department of Neurology, University of Lübeck, Lübeck, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew" last="Hicks">Andrew Hicks</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Thompson, John R" sort="Thompson, John R" uniqKey="Thompson J" first="John" last="Thompson">John Thompson</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Department of Health Sciences, University of Leicester, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Medicine</title><idno type="ISSN">1549-1277</idno><idno type="e-ISSN">1549-1676</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title></title><p>In this study, Mendelian randomization was used to study genes known to modify iron levels, and the effect of iron on Parkinson's disease (PD) risk was estimated. Based on estimates of the genetic effects on both iron and PD obtained from the largest sample meta-analyzed to date, the findings suggest that increased iron levels in the blood are associated with a 3% reduction in the risk of Parkinson's disease for every 10 µg/dL increase in iron. 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Londres</li><li>Indiana</li><li>Maryland</li><li>Massachusetts</li><li>Pennsylvanie</li></region><settlement><li>Berlin</li><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Pichler, Irene" sort="Pichler, Irene" uniqKey="Pichler I" first="Irene" last="Pichler">Irene Pichler</name></region><name sortKey="Del Greco M, Fabiola" sort="Del Greco M, Fabiola" uniqKey="Del Greco M F" first="Fabiola" last="Del">Fabiola Del</name><name sortKey="Gogele, Martin" sort="Gogele, Martin" uniqKey="Gogele M" first="Martin" last="Gögele">Martin Gögele</name><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew" last="Hicks">Andrew Hicks</name><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter" last="Pramstaller">Peter Pramstaller</name><name sortKey="Thompson, John R" sort="Thompson, John R" uniqKey="Thompson J" first="John" last="Thompson">John Thompson</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Lill, Christina M" sort="Lill, Christina M" uniqKey="Lill C" first="Christina" last="Lill">Christina Lill</name></region><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><name sortKey="Lill, Christina M" sort="Lill, Christina M" uniqKey="Lill C" first="Christina" last="Lill">Christina Lill</name><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter" last="Pramstaller">Peter Pramstaller</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Do, Chuong B" sort="Do, Chuong B" uniqKey="Do C" first="Chuong" last="Do">Chuong Do</name></region><name sortKey="Eriksson, Nicholas" sort="Eriksson, Nicholas" uniqKey="Eriksson N" first="Nicholas" last="Eriksson">Nicholas Eriksson</name><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><name sortKey="Keller, Margaux F" sort="Keller, Margaux F" uniqKey="Keller M" first="Margaux" last="Keller">Margaux Keller</name><name sortKey="Keller, Margaux F" sort="Keller, Margaux F" uniqKey="Keller M" first="Margaux" last="Keller">Margaux Keller</name><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard" last="Myers">Richard Myers</name><name sortKey="Nalls, Michael" sort="Nalls, Michael" uniqKey="Nalls M" first="Michael" last="Nalls">Michael Nalls</name></country><country name="Australie"><noRegion><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name></noRegion><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John" last="Whitfield">John Whitfield</name></country><country name="Italie"><noRegion><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter" last="Pramstaller">Peter Pramstaller</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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